Question
The “bioorthogonal” form of this discipline uses cyclooctyne derivatives so that ring strain promotes the reaction without needing a cytotoxic copper catalyst, thus allowing it to be performed inside living cells. For 10 points each:
[10e] Name this subdiscipline of green chemistry that is focused on maximizing atom economy by joining together smaller units to form compounds without creating byproducts, essentially having basic components “snap” together.
ANSWER: click chemistry
[10m] The most fundamental reaction of click chemistry is the copper(I)-catalyzed cycloaddition of this functional group to an alkyne, a reaction named for Huisgen.
ANSWER: azide
[10h] This chemist pioneered the use of cyclooctyne derivatives in click chemistry and made the Staudinger ligation. This chemist, Morten Meldal, and Barry Sharpless won the 2022 Chemistry Nobel for their work on click chemistry.
ANSWER: Carolyn Ruth Bertozzi
<Gerhardt Hinkle, Chemistry>
Summary
| 2023 Penn Bowl @ Waterloo | 10/28/2023 | Y | 4 | 17.50 | 75% | 50% | 50% |
| 2023 Penn Bowl @ FSU | 10/28/2023 | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2023 Penn Bowl (Norcal) | 10/28/2023 | Y | 2 | 25.00 | 100% | 50% | 100% |
| 2023 Penn Bowl (South Central) | 10/28/2023 | Y | 3 | 6.67 | 33% | 0% | 33% |
| 2023 Penn Bowl (UK) | 10/28/2023 | Y | 5 | 14.00 | 60% | 20% | 60% |
Data
| Berkeley A | Stanford | 10 | 10 | 10 | 30 |
| Berkeley C | Berkeley B | 10 | 0 | 10 | 20 |