Question
The most profitable and promising drugs made by the pharma company Eisai (“AY-sigh”) treat this disease. In 2021, three FDA advisors resigned to protest the approval of an erstwhile-blockbuster Biogen drug that failed to improve this disease’s prognosis. Sylvain Lesné faked Western blots to prove the toxic oligomer Aβ*56 (“A-beta-star-56”) causes this disease. In 2022, the clinical success of lecanemab (“luh-CAN-uh-mab”) validated a long-standing hypothesis that this disease occurs when (*) secretases (“SEH-cruh-tazes”) cleave a precursor protein and leave its insoluble beta peptide behind. Two hallmarks of this disease are fibrous tangles of tau protein and aggregated amyloid plaques. This disease’s “early onset” occurs before age 65. For 10 points, name this neurodegenerative disease, the leading cause of dementia. ■END■
Summary
2023 PACE NSC | 06/10/2023 | Y | 35 | 100% | 37% | 0% | 73.77 |
Buzzes
Player | Team | Opponent | Buzz Position | Value |
---|---|---|---|---|
Arthur Gayden | Detroit Country Day | Winnebago | 34 | 20 |
Chakri Gudlavalleti | Dunbar | Cincinnati Hills Christian | 35 | 20 |
Jacob Hardin-Bernhardt | Hunter A | Washington | 36 | 20 |
Samarth Ram | Plymouth | Innovation Academy B | 40 | 20 |
Samuel Li | Thomas Jefferson D | University Lab | 46 | 20 |
Abigail Lee | Thomas Jefferson C | Waukee | 46 | 20 |
Aditya Shivaswamy | St. Mark's | Belvidere | 50 | 20 |
Sarah Dong | Solon | Stevenson A | 50 | 20 |
Sophie Higgs | Richard Montgomery | Hunter B | 50 | 20 |
Kaiwen Xiao | Irvington A | Norman | 57 | 20 |
Tyler Song | Winston Churchill B | Chattahoochee A | 58 | 20 |
Cole Hartung | Kinkaid | Maggie Walker B | 58 | 20 |
Andrew Tsui | Canyon Crest | Maggie Walker C | 59 | 20 |
Brielle Rach | Rockford Auburn B | Dallas County | 76 | 10 |
Ave Rieger | Northmont A | Detroit Catholic Central C | 77 | 0 |
Karl Barnickol | Walter Payton | Detroit Catholic Central A | 78 | 10 |
Aiden Dombrosky | Hoover B | Johns Creek A | 78 | 10 |
Lucas Ardelean | Innovation Academy A | Northmont B | 78 | 10 |
Rohan Dalal | Johns Creek B | Elkhorn North | 78 | 10 |
Jiming Chen | Hinsdale Central | Troy | 82 | 10 |
Alec Riso | Thomas Jefferson B | Barrington B | 88 | 10 |
Charles Heydt | Midtown | Norris | 88 | 10 |
Vien Nguyen | Maggie Walker A | John Adams A | 88 | 10 |
Andy Yu | Winston Churchill A | New Brighton | 89 | 10 |
Bryce Cruise | Heights | Stevenson B | 89 | 10 |
Rohan Kher | Barrington A | West Point | 89 | 10 |
Brian O'Connell | Woodland | John Adams B | 89 | 10 |
Ryan Dai | Carbondale | Rockford Auburn A | 89 | 10 |
Dylan Cheng | Thomas Jefferson A | Lincoln-Way East | 89 | 10 |
Anthony Chalhoub | Detroit Catholic Central B | Mexico | 90 | 10 |
Anvith Vanukuri | William Fremd | Chattahoochee B | 91 | 10 |
Armaan Ahmed | Mercer County | Mira Loma | 91 | 10 |
Aryan Pathak | Lake Highland | Belmont | 93 | 10 |
JT Baysinger | Moberly | Choate Rosemary Hall | 108 | 10 |
Anish Jindal | Parkway West | Saint Joseph | 108 | 10 |
Chris Goolsby | Detroit Catholic Central C | Northmont A | 114 | 10 |