TPO is an enzyme that is expressed in this organ. A substance named after Jean Lugol is historically used to treat overactivity of this organ (10[1])in an example of the (10[1])Plummer effect. That effect helps explain why the administration of amiodarone (ah-me-oh-DAH-rohn) can cause irregular activity by this organ. A failure of this organ can cause a myxedema coma. An autoimmune disease that destroys this organ creates Hürthle cells, while thiamazole is used to treat a different autoimmune disease that (10[1])causes overactivity of this organ that leads to bulging eyes. (10[1])Those (10[1])diseases of this (10[1])organ, which (10[1])cause a dangerously low or high basal metabolic rate, are respectively Hashimoto's (10[1])disease and Graves's (10[1])disease. A certain dietary deficiency can lead to the formation of a goiter in this organ. For 10 points, name this gland located on the neck that requires iodine. ■END■