Description acceptable. Both the ISR pathway and a pathway triggered in response to this more specific condition are triggered by the alkaloid halofuginone. Pediatric A·L·L is most commonly treated using a combination of vincristine, a steroid, and a drug that induces this condition. The enzyme Rel·A is activated when it recognizes an unligated molecule whose presence indicates this condition. The protein GCN2 is named for a “general control” pathway triggered by this condition, and triggers the deactivation of (*) m·TOR. In bacteria and plants, this is the primary condition that triggers the production of the alarmone guanosine pentaphosphate, which activates the stringent response. Cells experiencing this type of cellular stress typically have increased amounts of uncharged t·RNAs and may undergo ribosome stalling. For 10 points, name this cellular stress caused by a lack of molecules that comprise polypeptides. ■END■
ANSWER: amino acid starvation [accept answers that describe a lack of amino acids; accept answers that describe a lack of specific amino acids like asparagine deficiency; prompt on cellular stress; prompt on starvation or nutrient starvation by asking “starvation of what?”]
<Geoffrey Chen, Biology>
= Average correct buzz position