Question
This family of compounds is divided into ones with nine-membered rings, like Neocarzinostatin, and ones with ten-membered rings, like Calicheamicin. For 10 points each:
[10h] Name these compounds with antitumor activity that undergo the Bergman cyclization to generate reactive 1,4-benzoid diradicals, which causes crosslinking in DNA.
ANSWER: enediynes
[10m] This other chemotherapeutic compound is activated by aquation before it creates crosslinks in DNA by binding to the N7 position of guanines. Common derivatives of this compound replace its chloride ligands with bidentate CBDCA or oxalate ligands.
ANSWER: cisplatin (The derivatives are carboplatin and oxaliplatin, respectively.)
[10e] Exposure to this form of radiation can result in DNA crosslinking as well as the formation of thymine dimers.
ANSWER: ultraviolet radiation [or UV radiation]
<Jason Hong, Chemistry>
Summary
| 2023 Chicago Open | 08/05/2023 | Y | 1 | 30.00 | 100% | 100% | 100% |
Data
| The Plague (anime)" was redirected to: "Oran High School Host Club | The Catastrophic Implosion of Packet Sub | 10 | 10 | 10 | 30 |