Question
Multiple myeloma cells are fused with these cells to form a hybridoma cell line. For 10 points each:
[10m] Name these lymphocytes. When these cells enter germinal centers, they undergo somatic hypermutation and differentiate into either memory cells or plasma cells.
ANSWER: B cells [or B lymphocytes; prompt on lymphocytes or white blood cells or WBCs]
[10e] Plasma B cells secrete lots and lots of these proteins. Somatic hypermutation diversifies the variable regions of these Y-shaped proteins to then select for ones with high affinity for their antigens.
ANSWER: antibodies [or antibody; or immunoglobulins; prompt on Ab or Ig]
[10h] Two opposing models argue that somatic hypermutation is either mediated by a deaminase or by one of these enzymes. The viral Pol gene encodes a protease, an integrase, and one of these enzymes with an attached RNase (“R-N-ase”) domain.
ANSWER: reverse transcriptase [or RT; accept RNA-dependent DNA polymerase; prompt on DNA polymerase]
<Biology>
Summary
| 2023 ACF Winter @ Columbia | 11/11/2023 | Y | 4 | 20.00 | 100% | 50% | 50% |
Data
| Columbia B | NYU A | 0 | 10 | 0 | 10 |
| Rutgers A | Bard A | 10 | 10 | 0 | 20 |
| Yale A | Columbia A | 0 | 10 | 10 | 20 |
| Cornell C | Yale C | 10 | 10 | 10 | 30 |