Question
Some of the first functions to decline during this process are IL-2 production and ex vivo killing abilities. For 10 points each:
[10m] Name this process during which persistent viral or tumor-mediated antigenic stimulation of T cells causes attenuation of their effector functions. Unlike anergy, high expression of Tox is associated with this process.
ANSWER: T cell exhaustion [accept CD8+ T cell exhaustion or CD4+ T cell exhaustion; accept word forms of exhaust in place of “exhaustion”]
[10e] In the setting of HCV or HBV infection, higher values of this quantity correlate to more severe T cell exhaustion. NAAT tests for HIV measure this quantity that is given in RNA copies per milliliter.
ANSWER: viral load [or viral burden; or viral titre or viral titer; accept peak viremia]
[10h] Tumors-mediated T cell exhaustion represents a major limit to this form of therapy that can currently treat relapsed or refractory multiple myeloma, follicular lymphoma, and acute lymphoblastic leukemia.
ANSWER: CAR-T therapy [or chimeric antigen receptor T-cell therapy; accept adoptive cell therapy or ACT; prompt on chimeric antigen receptors or CARs or chimeric immunoreceptors; prompt on cancer immunotherapy]
<Biology>
Summary
| 2023 ACF Nationals | 04/22/2023 | Y | 21 | 10.48 | 76% | 14% | 14% |
Data
| Chicago C | Florida B | 0 | 10 | 0 | 10 |
| McGill A | Ohio State A | 0 | 0 | 10 | 10 |
| Rutgers A | Houston A | 0 | 10 | 0 | 10 |
| Claremont A | NYU A | 0 | 0 | 0 | 0 |
| Harvard A | Chicago A | 10 | 10 | 0 | 20 |
| Maryland A | Minnesota A | 0 | 10 | 0 | 10 |
| Imperial A | North Carolina A | 0 | 10 | 0 | 10 |
| Penn A | Vanderbilt A | 0 | 0 | 0 | 0 |
| Stanford A | Brown A | 10 | 10 | 10 | 30 |
| Yale A | Texas A | 0 | 10 | 10 | 20 |
| Florida A | Columbia B | 0 | 10 | 0 | 10 |
| Cornell A | Johns Hopkins A | 0 | 10 | 0 | 10 |
| Michigan A | Penn State A | 0 | 10 | 0 | 10 |
| UC Berkeley B | Rutgers B | 0 | 0 | 0 | 0 |
| Columbia A | WUSTL B | 0 | 0 | 0 | 0 |
| Northwestern A | Minnesota B | 0 | 10 | 0 | 10 |
| Purdue A | Indiana A | 0 | 10 | 0 | 10 |
| Toronto A | WUSTL A | 10 | 10 | 0 | 20 |
| Duke A | MIT A | 0 | 10 | 0 | 10 |
| Chicago B | UC Berkeley A | 0 | 10 | 0 | 10 |
| Virginia A | Iowa State A | 0 | 10 | 0 | 10 |