In plants, a form of this molecule can be cleaved by proteins from the DEMETER family. Combining this molecule with arabinose generates an anti·metabolite often used to treat acute myeloid leukemia. In a technique developed by Chuan He’s lab, the oxidation of a derivative of this molecule by TET proteins converts it into a 5-carboxyl form reactive to bisulfite. Enzymes from the AID/APOBEC family facilitate the (*) deamination of this molecule. This molecule, which is subjected to methylation by DNMTs during epigenetic control, is the lighter of the two nucleobases found at “island” sequences that it co-names. This pyrimidine can appear in both DNA and RNA, unlike thymine and uracil. For 10 points, name this nucleobase that pairs with guanine. ■END■
| 2025 Penn Bowl - Stanford | 10/25/25 | Y | 4 | 75% | 0% | 50% | 84.33 |
| 2025 Penn Bowl - Northwestern | 10/25/25 | Y | 4 | 50% | 0% | 100% | 119.00 |
| 2025 Penn Bowl - Mainsite (UPenn) | 11/01/25 | Y | 6 | 100% | 0% | 83% | 118.67 |
| 2025 Penn Bowl - Ottawa | 11/01/25 | Y | 7 | 71% | 0% | 57% | 92.80 |
| 2025 Penn Bowl - UK | 11/01/25 | Y | 9 | 78% | 0% | 44% | 110.29 |
| 2025 Penn Bowl - UNC | 11/01/25 | Y | 3 | 100% | 0% | 33% | 96.33 |
| 2025 Penn Bowl - WashU | 11/01/25 | Y | 2 | 100% | 50% | 0% | 89.00 |
| 2025 Penn Bowl - BU | 11/01/25 | Y | 4 | 100% | 0% | 25% | 103.00 |
| 2025 Penn Bowl - CWRU | 11/01/25 | Y | 3 | 100% | 0% | 33% | 96.33 |
| 2025 Penn Bowl - Murray State | 11/08/25 | N | 2 | 100% | 0% | 50% | 119.00 |
| 2025 Penn Bowl - Online | 11/08/25 | N | 2 | 100% | 0% | 0% | 103.00 |
| Player | Team | Opponent | Buzz Position | Value |
|---|---|---|---|---|
| Moses Kitakule | Columbia A | NYU B | 33 | -5 |
| Eric Yang | Purdue A | UChicago A | 43 | -5 |
| Ben Hellman | Swarthmore | Columbia B | 49 | -5 |
| Raymond Chen | Toronto Operation PBSuccess | Toronto Murder on the Rider Express | 59 | -5 |
| Paul Lee | WashU Bouba | Truman State | 59 | 15 |
| Vinu Harihar | Berkeley B | Stanford A | 66 | 10 |
| Richard Niu | The best time to buzz was twenty clues ago. The second best time to buzz is now | Free Win | 68 | 10 |
| Samarth Ram | UChicago B | Purdue B | 68 | -5 |
| Jonathan Lau | Maryland A | Mount Sinai | 69 | -5 |
| Jonathan Huang | MIT A | Brown | 69 | 10 |
| Tony Chen | Toronto G | #OpenToBuzz | 69 | 10 |
| Halee Carey | Ottawa 67s | Waterloo you are crooked | 69 | -5 |
| Travis Johnson | Pittsburgh | Michigan A | 69 | 10 |
| Max Fitz-James | Burnaburiash's Lapis Lazuli | Alas poor Warwick, I knew him Edinburgh | 76 | -5 |
| Alec Zelek | Toronto E | Toronto Sunshine Bubbles | 78 | 10 |
| Fern Fang | Planck Sinatra | VT B | 78 | -5 |
| Aditya Sharma | Wise Duke | UNC B | 78 | 10 |
| Charlie Ruff | McGill Fartlets | Aweille Kevin Fan osti continue comme ça | 79 | 10 |
| Aneesh Swaminathan | JHU A | Maryland B | 80 | -5 |
| Sam Moore | Knorr Stock Clue | Bristold | 80 | 10 |
| Matthew Schiavone | Northwestern A | UChicago C | 81 | -5 |
| Alex Akridge | Indiana | Northwestern B | 81 | -5 |
| Swapnil Garg | Berkeley A | Berkeley C | 84 | -5 |
| Jacob Goodson | Ohio State B | Michigan B | 84 | -5 |
| Nathan Easow | why is it called a score clue if nobody scores points on it | Hail to the Sheaf | 84 | -5 |
| Cade Reinberger | RIT | I've been running into you in my lead plumbocene what could have benzene | 87 | -5 |
| Ryan Rosenberg | NYU A | John Jay | 88 | -5 |
| Ilyas Choukri | VT A | UNC A | 92 | 10 |
| Daniel Hothem | In Search of Lost Clues | Stanford B | 95 | -5 |
| Joel Dicker | Coughing Baby | question mark | 101 | -5 |
| Pace Klein | CWRU | Michigan C | 101 | 10 |
| Brendan Bridle | Queen's is monitoring the situation | Guelph perfomative male competition | 104 | -5 |
| Henry Jiang | MIT B | Yale | 105 | 10 |
| Max Averbach | Northwestern B | Indiana | 108 | 0 |
| Ava Butler | McGill B | Carleton A | 108 | -5 |
| Philip Jordan | Quiztian Bale in Ratman Begins | Washed Scrubs | 108 | 10 |
| Agnijo Banerjee | Penn and the Art of Tossup-Bonus cycle Maintenance | Galactic Ombudsmen | 109 | 10 |
| Gannon Smith | Maryland B | JHU A | 118 | 10 |
| Chauncey Lo | Columbia B | Swarthmore | 118 | 10 |
| Ethan Webb | Of Mice and Penn | The Bit and the Penndulum | 118 | 10 |
| Aiden Bang | JHU B | Maryland C | 119 | 10 |
| Daniel Ma | Mount Sinai | Maryland A | 119 | 10 |
| Jerry Vinokurov | John Jay | NYU A | 119 | 10 |
| Nikolas Polsinelli | UChicago C | Northwestern A | 119 | 10 |
| Joy An | Harvard | Brandeis | 119 | 0 |
| Jonathan Schnipper | Brandeis | Harvard | 119 | 10 |
| Kevin Le | Carleton A | McGill B | 119 | 10 |
| Caleb Ott | Waterloo you are crooked | Ottawa 67s | 119 | 10 |
| Gabriel McMurren | Guelph perfomative male competition | Queen's is monitoring the situation | 119 | 0 |
| Chris Wang | Toronto Murder on the Rider Express | Toronto Operation PBSuccess | 119 | 0 |
| Aaryan Sumesh | Berkeley C | Berkeley A | 119 | 10 |
| Danny Han | Stanford B | In Search of Lost Clues | 119 | 0 |
| Lucas Johns | Alas poor Warwick, I knew him Edinburgh | Burnaburiash's Lapis Lazuli | 119 | 0 |
| Linus Luu | question mark | Coughing Baby | 119 | 10 |
| Walter Zhang | I've been running into you in my lead plumbocene what could have benzene | RIT | 119 | 10 |
| Thomas Jenkins | Michigan B | Ohio State B | 119 | 10 |
| Kelvin Ni | NYU B | Columbia A | 119 | 10 |
| Vivek Sasse | Hail to the Sheaf | why is it called a score clue if nobody scores points on it | 119 | 0 |
| Justin Keung | Chimp Brisket | Paul Quifford, or, It Was a Dark and Stormy Tournament | 119 | 10 |
| Daoud Jackson | To buzz is to be perceived | 1. Wawa 2. Blank Street 151. Black Sheep at Kings Cross rail | 119 | 10 |
| Landon Campbell | VT B | Planck Sinatra | 119 | 10 |
| Neal Joshi | VJ Edgecombe School of Interior Design - Edwardsville | WashU Kiki | 119 | 10 |
| Aden Sun | UChicago A | Purdue A | 119 | 10 |
| Aneesh Shrotriya | Purdue B | UChicago B | 119 | 0 |