Parkinson’s disease - 2025 Penn Bowl

Question

In the 1980s, it was determined that a severe form of this disease affecting young opioid users was caused by the accidental self-administration of MPTP. For 10 points each:

[10e] Name this neurodegenerative disease often described as a “shaking palsy” since it is characterized by tremors and muscle rigidity.

ANSWER: Parkinson’s disease [or PD; accept Parkinsonism]

[10m] Once in the body, MPTP converts to MPP-plus, a toxin that inhibits dopaminergic neurons found in this part of the basal ganglia. Like the locus coeruleus, this structure is a major reservoir for neuromelanin.

ANSWER: substantia nigra [accept pars compacta; accept pars reticulata]

[10h] MPTP is converted to the toxic MPP-plus by a “B” form of one of these enzymes. Brunner syndrome is caused by a mutation in an “A” form of one of these enzymes responsible for metabolizing serotonin.

ANSWER: MAOs [or monoamine oxidases; accept MAO-A or monoamine oxidase A; accept MAO-B or monoamine oxidase B; prompt on oxidases]

Back to bonuses

Summary


2025 Penn Bowl - BU	11/01/25	Y	4	17.50	100%	50%	25%
2025 Penn Bowl - CWRU	11/01/25	Y	3	13.33	100%	33%	0%
2025 Penn Bowl - Mainsite (UPenn)	11/01/25	Y	6	18.33	100%	50%	33%
2025 Penn Bowl - Murray State	11/08/25	Y	2	10.00	100%	0%	0%
2025 Penn Bowl - Northwestern	10/25/25	Y	4	15.00	100%	50%	0%
2025 Penn Bowl - Online	11/08/25	Y	2	20.00	100%	100%	0%
2025 Penn Bowl - Ottawa	11/01/25	Y	7	15.71	100%	29%	29%
2025 Penn Bowl - Stanford	10/25/25	Y	4	22.50	100%	100%	25%
2025 Penn Bowl - UK	11/01/25	Y	9	13.33	89%	33%	11%
2025 Penn Bowl - UNC	11/01/25	Y	3	23.33	100%	100%	33%
2025 Penn Bowl - WashU	11/01/25	Y	2	25.00	100%	100%	50%

Data


Brandeis	MIT B	10	0	0	10
Brown	RIT	10	10	0	20
Harvard	Yale	10	0	0	10
MIT A	I've been running into you in my lead plumbocene what could have benzene	10	10	10	30
NYU B	Mount Sinai	10	0	0	10
JHU A	Swarthmore	10	10	10	30
Columbia A	JHU B	10	10	10	30
Columbia B	John Jay	10	0	0	10
Maryland A	Maryland C	10	10	0	20
Maryland B	NYU A	10	0	0	10
Central Oklahoma	Texas B	10	0	0	10
Texas A	Oklahoma	10	0	0	10
Illinois	Northwestern A	10	10	0	20
UChicago C	Northwestern B	10	0	0	10
Purdue A	UChicago B	10	0	0	10
Indiana	Purdue B	10	10	0	20
New Young Whigs of America	abg academy	10	10	0	20
rusty shackleford	Wake Up Paddington A Washington Mystery	10	10	0	20
Berkeley A	Stanford B	10	10	10	30
Berkeley B	The best time to buzz was twenty clues ago. The second best time to buzz is now	10	10	0	20
Free Win	Stanford A	10	10	0	20
In Search of Lost Clues	Berkeley C	10	10	0	20
#OpenToBuzz	Toronto E	10	0	0	10
Aweille Kevin Fan osti continue comme ça	Guelph perfomative male competition	10	0	10	20
McGill B	Ottawa 67s	10	0	0	10
Toronto Murder on the Rider Express	McGill Fartlets	10	0	0	10
Queen's is monitoring the situation	Toronto Sunshine Bubbles	10	0	0	10
Toronto Operation PBSuccess	Carleton A	10	10	10	30
Toronto G	Waterloo you are crooked	10	10	0	20
Burnaburiash's Lapis Lazuli	To buzz is to be perceived	10	0	0	10
Quiztian Bale in Ratman Begins	Coughing Baby	10	0	0	10
Hail to the Sheaf	Alas poor Warwick, I knew him Edinburgh	0	0	10	10
Knorr Stock Clue	Chimp Brisket	10	0	0	10
Of Mice and Penn	Bristold	10	0	0	10
Washed Scrubs	Penn and the Art of Tossup-Bonus cycle Maintenance	10	10	0	20
The Bit and the Penndulum	Paul Quifford, or, It Was a Dark and Stormy Tournament	10	10	0	20
Galactic Ombudsmen	question mark	10	0	0	10
why is it called a score clue if nobody scores points on it	1. Wawa 2. Blank Street 151. Black Sheep at Kings Cross rail	10	10	0	20
CWRU	Ohio State A	10	10	0	20
UNC A	Planck Sinatra	10	10	0	20
VT A	UNC B	10	10	10	30
Wise Duke	VT B	10	10	0	20
VJ Edgecombe School of Interior Design - Edwardsville	Truman State	10	10	10	30
WashU Kiki	WashU Bouba	10	10	0	20
Michigan A	Michigan B	10	0	0	10
Michigan C	Ohio State B	10	0	0	10