The assembly of these structures is often analyzed by tracking EGFP-tagged “comets” of End-binding protein 1. For 10 points each:
[10e] Name these structures that are cut by katanin and nucleate from namesake “organizing centers.” Dyneins and kinesins “walk” toward opposite ends of these polymers.
ANSWER: microtubules [accept microtubule organizing centers; prompt on MTOCs or MTs]
[10m] Microtubule assembly is regulated by this process, which has “catastrophe” and “rescue” phases. In this two-word process, tubulin at the ends of microtubules is hydrolyzed from GTP-bound to GDP-bound states.
ANSWER: dynamic instability
[10h] A protein whose name is this acronym and “170” links growing microtubule ends to endosomes. A different peptide with this name is exchanged with antigens on the grooves of class II MHCs via HLA-DM.
ANSWER: CLIP [accept CLIP-170 or cytoplasmic linker protein 170; accept Class II-associated invariant chain peptide]
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