This test requires constructing a contingency table whose values are the number of synonymous versus nonsynonymous substitutions and polymorphisms in the gene of interest. For 10 points each:
[10h] Name this doubly-eponymous statistical test used to distinguish between positive and negative forms of natural selection by comparing variation within a species and between species.
ANSWER: McDonald–Kreitman test [prompt on MKT]
[10m] Departure from the null hypothesis of the McDonald–Kreitman test is quantified by an index named for this adjective. A theory of molecular evolution described by this adjective was developed by Motoo (“mo-TOH”) Kimura.
ANSWER: neutral [accept neutrality index; accept neutral theory of molecular evolution]
[10e] McDonald and Kreitman developed their namesake test while studying the gene that codes for alcohol dehydrogenase, which oxidizes this two-carbon alcohol produced during fermentation into acetaldehyde.
ANSWER: ethanol [or ethyl alcohol; or EtOH; or C2H6O]
<MS, Biology>