Proteins with this property can be modeled with the early computation tool TMHMM. Proteins with this property are divided into monotopic, bitopic, (-5[1])and polytopic subgroups. Because proteins with this property are insoluble, they must be tagged with Cub and Nub (-5[1])domains to be analyzed (-5[1])in the (10[1])split-ubiquitin yeast two-hybrid screen. (-5[1])Proteins with this property can be stabilized via the addition of lipid anchors such as farnesyl (10[1]-5[1])or palmitoyl (10[1])groups. Proteins with this property are NOT removed by detergent washes, unlike their “peripheral” counterparts. (10[3])Alpha helices (10[1])that are roughly 17 residues (10[1])long are often present in proteins with this (10[1])property, (10[1])as exemplified by the seven alpha helices (10[1])in GPCRs (10[1])and the six in aquaporins. For 10 points, name these proteins that contain domains on both the interior (10[3])and (10[1]-5[1])exterior of a phospholipid bilayer. ■END■ (10[3]0[7])