CAND1 (“cand-one”) is released from these proteins’ “ring ligases” when these proteins undergo NEDDylation. For 10 points each:
[10h] Name these scaffolding proteins that are found alongside SKP1 and F-box in the SCF complex.
ANSWER: cullins
[10e] NEDDylation of cullin is an example of SUMOylation, which is named for mimicking the binding of this protein to its substrates. This protein can mark other proteins for degradation as the “molecular kiss of death.”
ANSWER: ubiquitin [or Ub; accept ubiquitination; accept ubiquitin ligases]
[10m] Ubiquitin directs substrates to the 26S subunit of this structure, which is responsible for recycling ubiquitin and the amino acids from misfolded peptides.
ANSWER: proteasome (“PRO-tee-uh-sohm”) [accept 26S proteasome]
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