Question
Transcription of these genes relies only on existing transcription factors and proceeds in the presence of synthesis inhibitors. For 10 points each:
[10h] Name these genes that mediate short-scale cell signaling. The N antiterminator is an example of these genes in the lambda phage, while c-Fos (“C-foss”) is a human one used as a marker of neuronal activation.
ANSWER: immediate early genes [or IE genes]
[10m] c-Fos can dimerize with c-Jun (“C-joon”) by forming this structural motif. Transcription factors that incorporate this motif, such as AP-1 and CREB (“creb”), contain a heptad (“HEP-tad”) repeat with two hydrophobic residues.
ANSWER: leucine zipper [accept basic leucine zipper domain; prompt on coiled coils]
[10e] The Fos-Jun leucine (“LEW-seen”) zipper is a canonical example of how this secondary structural motif can form a coiled coil. Each residue in these structures rotates about 100 degrees relative to the last.
ANSWER: alpha helix [or alpha helices; prompt on helix or helices]
<Biology>
Summary
| 2024 ACF Nationals | 2024-04-21 | Y | 20 | 10.50 | 80% | 20% | 5% |
Data
| Brown | McGill | 0 | 10 | 10 | 20 |
| Minnesota A | Chicago C | 0 | 0 | 10 | 10 |
| Columbia A | Claremont Colleges | 0 | 0 | 10 | 10 |
| Columbia B | Michigan | 0 | 0 | 0 | 0 |
| Cornell A | Toronto B | 0 | 0 | 0 | 0 |
| Rutgers | Harvard | 0 | 0 | 10 | 10 |
| Illinois | Ottawa | 0 | 10 | 10 | 20 |
| Indiana | Florida | 0 | 0 | 0 | 0 |
| Toronto A | Kentucky | 0 | 0 | 10 | 10 |
| Duke | Minnesota B | 0 | 0 | 10 | 10 |
| Johns Hopkins | NYU | 0 | 10 | 10 | 20 |
| Berkeley A | North Carolina B | 0 | 0 | 10 | 10 |
| Northwestern | Stanford | 10 | 10 | 10 | 30 |
| Maryland | Penn | 0 | 0 | 0 | 0 |
| Purdue | Truman State | 0 | 0 | 10 | 10 |
| Chicago A | South Carolina | 0 | 0 | 10 | 10 |
| Texas | Cornell B | 0 | 0 | 10 | 10 |
| Yale B | Vanderbilt | 0 | 0 | 10 | 10 |
| North Carolina A | Virginia | 0 | 0 | 10 | 10 |
| Yale A | WUSTL B | 0 | 0 | 10 | 10 |