The benzimidazole (“benz-imid-azole”) family of anthelmintics limit the ability of this protein to aggregate. For 10 points each:
[10h] Name this protein also targeted by colchicine and vincristine. The hydrolysis of GTP bound to this protein produces the curvature of the plus end and allows heterodimers to dissociate.
ANSWER: beta-tubulin [prompt on tubulin]
[10m] Microtubule-associated tau proteins with this property aggregate into tangles linked to the pathogenesis of many dementias. This property describes proteins that have been completely saturated by a kinase, and is used to inhibit Rb during the G1/S checkpoint.
ANSWER: hyperphosphorylated [or hyperphosphorylation; prompt on multi-phosphorylated or phosphorylation]
[10e] G1 is one of two “gap” phases during this long period of growth in between bouts of cell division.
ANSWER: interphase
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