Answer some questions about the body’s interactions with amatoxin, which is found in numerous poisonous mushrooms. For 10 points each:
[10e] The first organ to fail in amatoxin poisoning is this organ that detoxifies xenobiotics. This organ can suffer from cirrhosis and is mostly made up of hepatocytes.
ANSWER: liver
[10m] The second phase of amatoxin poisoning affects this organ that can suffer from Wilms’ tumor. This organ contains major and minor calyces and numerous capillaries that form a glomerulus (“glom-AIR-yoo-loos”).
ANSWER: kidney
[10h] Amatoxin enters cells via the OAT-P transporter, which also transports these 20-carbon molecules synthesized by cyclooxygenases. These molecules include an E1 subtype and cause vasodilation.
ANSWER: prostaglandins
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