Question

This portion of the endoplasmic reticulum is implicated in calcium transport, autophagy, and lipid transfer. For 10 points each:
[10h] Name this ER region that resembles lipid rafts in its composition and is dynamically tethered to a namesake organelle through proteins expressing FFAT motifs.
ANSWER: mitochondria-associated membrane [or MAM; or mitochondria-associated ER membrane; or mitochondria-ER contacts; or MERCS, ER-mitochondria contacts; or ERMES; reject just “mitochondria”]
[10m] Reduced contacts between the ER and mitochondria can increase levels of this process controlled by Bcl2, where ROS-damaged mitochondria are degraded by the lysosome.
ANSWER: mitophagy [prompt on apoptosis or autophagy]
[10e] This disease is caused by mutations in MAM genes inhibiting mitophagy, leading to the formation of Lewy bodies and the gradual destruction of the substantia nigra. This neurodegenerative disease is characterized by rigidity and tremors.
ANSWER: Parkinson’s disease [or PD]
<Vishal Kanigicherla, Biology>

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Library of Babel School of Continuing StudiesLa Clique du Château001010
Mixed-Affiliated Contingency, Off the Team & Absent: Wong, AdrianToronto Joy001010
Toronto RoflWaterloo Miku001010
Waterloo HatsuneToronto Weary001010
Florida ANorth Florida001010
FSU BFSU A0000
BrownBrandeis001010
MITHarvard001010
Boston CollegeTufts001010
Cornell AColumbia A001010
Berkeley ABerkeley C001010
StanfordBerkeley B001010
Oklahoma ATexas C001010
Oklahoma BRice001010
Texas BTexas A001010
Cornell BColumbia B001010
JHU BSwarthmore0101020
NYUPitt001010
John Jay ARIT001010
UMD ARutgers001010
JHU AUMD B001010
Foucoult's Penndulum3HK1MM001010
Old London TownBroken Hearts001010
EdinburghScottish, Irish, Both or Neither001010
Four Neg OmeletteTabearnacle001010
Betrayed by Rita IzzatdustYes, Moderator0000
USC ADuke A001010
UNC BUNC A001010
UNC CUSC B001010