Question

Genomes of patients with this condition are collected in the GENIE (“genie”) database and by an NIH-run Genome Atlas. Cell-free ctDNA is sequenced after a liquid biopsy to identify mutations that cause this condition. Alfred Knudson popularized the idea that this condition is (20[1])caused by a second (20[1])“hit” (20[1])that causes the alleles for Rb (“R-B”) to lose hetero·zygosity. (20[1])This condition can be caused by hyperactivation of Ras (“razz”) kinase or by inactivation of the (*) pro-apoptotic suppressor gene BRCA (10[1])(“BRACK-uh”). p53 guards the genome mainly by preventing this condition. This condition occurs when cell cycle checkpoints are bypassed so that mitosis always proceeds. For 10 points, what disease condition occurs when oncogenes are mutated by carcinogens? ■END■

ANSWER: cancer [accept word forms like cancerous; accept any specific type of cancer such as breast cancer or ovarian cancer; accept tumor formation or tumorigenesis; carcinogenesis or oncogenesis; accept metastasis]
<Adam Silverman, Science - Biology&gt; ~25693~ &lt;Editor: Adam Silverman>
= Average correct buzz position

Buzzes

PlayerTeamOpponentBuzz PositionValue
Matthew KohnHunter ABelmont4120
Braden BoothDallas CountyUniversity Lab4520
Dennis YangTroyKinkaid4620
Aaryan SumeshThomas Jefferson CMira Loma5520
Sohum SukhatankarSt. Mark'sWinston Churchill A7410

Summary

2023 PACE NSC06/10/2023Y4100%75%0%54.00
2023 PACE NSC06/10/2023Y1100%100%0%45.00