Genomes of patients with this condition are collected in the GENIE (“genie”) database and by an NIH-run Genome Atlas. Cell-free ctDNA is sequenced after a liquid biopsy to identify mutations that cause this condition. Alfred Knudson popularized the idea that this condition is (20[1])caused by a second (20[1])“hit” (20[1])that causes the alleles for Rb (“R-B”) to lose hetero·zygosity. (20[1])This condition can be caused by hyperactivation of Ras (“razz”) kinase or by inactivation of the (*) pro-apoptotic suppressor gene BRCA (10[1])(“BRACK-uh”). p53 guards the genome mainly by preventing this condition. This condition occurs when cell cycle checkpoints are bypassed so that mitosis always proceeds. For 10 points, what disease condition occurs when oncogenes are mutated by carcinogens? ■END■