Question
To fix an enzyme in this pathway, in 1999 Jesse Gelsinger (“GELL-singer”) enrolled in a gene therapy clinical trial which had tragic consequences. For 10 points each:
[10m] Name this metabolic cycle that detoxifies ammonia in the liver.
ANSWER: urea cycle
[10h] Gelsinger had a lethal adverse reaction to one of these viruses used to package the new gene. The common cold can be caused by this family of DNA viruses, which have since been used safely in the AstraZeneca and J & J COVID-19 vaccines.
ANSWER: adenoviruses [or Adenoviridae; reject “adeno-associated viruses” or “AAVs”]
[10e] The Gelsinger tragedy kiboshed gene therapy for two decades until a treatment for this cancer was finally approved in 2017. Like lymphoma, this cancer of the bone marrow overproduces white blood cells.
ANSWER: leukemias [or acute lymphoblastic leukemias]
<Sudheer Potru, Science - Biology> ~20727~ <Editor: Adam Silverman>
Summary
| 2023 PACE NSC | 06/10/2023 | Y | 35 | 10.00 | 71% | 29% | 0% |
Data
| Woodland | Canyon Crest | 0 | 0 | 10 | 10 |
| Carbondale | Chattahoochee B | 0 | 0 | 10 | 10 |
| Chattahoochee A | Choate Rosemary Hall | 10 | 0 | 0 | 10 |
| Detroit Catholic Central B | Detroit Catholic Central C | 0 | 0 | 10 | 10 |
| Hunter B | Elkhorn North | 10 | 0 | 10 | 20 |
| Irvington A | Heights | 10 | 0 | 10 | 20 |
| Mercer County | Hoover B | 10 | 0 | 10 | 20 |
| Belmont | Hunter A | 0 | 0 | 10 | 10 |
| Carl Sandburg | Innovation Academy A | 0 | 0 | 10 | 10 |
| John Adams A | Innovation Academy B | 0 | 0 | 0 | 0 |
| John Adams B | Norman | 0 | 0 | 10 | 10 |
| Johns Creek A | Dunbar | 0 | 0 | 0 | 0 |
| Cincinnati Hills Christian | Lake Highland | 0 | 0 | 0 | 0 |
| Barrington B | Maggie Walker C | 0 | 0 | 10 | 10 |
| Midtown | Lincoln-Way East | 0 | 0 | 10 | 10 |
| Mira Loma | Thomas Jefferson B | 0 | 0 | 10 | 10 |
| Waukee | Moberly | 0 | 0 | 0 | 0 |
| Northmont A | Thomas Jefferson C | 0 | 0 | 10 | 10 |
| West Point | Northmont B | 10 | 0 | 0 | 10 |
| Mexico | Parkway West | 10 | 0 | 10 | 20 |
| Dallas County | Plymouth | 10 | 0 | 10 | 20 |
| Detroit Catholic Central A | Richard Montgomery | 0 | 0 | 0 | 0 |
| Rockford Auburn A | Barrington A | 0 | 0 | 10 | 10 |
| Maggie Walker B | Rockford Auburn B | 0 | 0 | 0 | 0 |
| Winston Churchill A | St. Mark's | 0 | 0 | 10 | 10 |
| Stevenson A | Winston Churchill B | 0 | 0 | 0 | 0 |
| Saint Joseph | Stevenson B | 0 | 0 | 10 | 10 |
| Thomas Jefferson A | Detroit Country Day | 10 | 0 | 10 | 20 |
| Thomas Jefferson D | Walter Payton | 0 | 0 | 10 | 10 |
| Troy | Solon | 10 | 0 | 10 | 20 |
| Kinkaid | University Lab | 10 | 0 | 10 | 20 |
| Belvidere | Washington | 0 | 0 | 10 | 10 |
| William Fremd | Maggie Walker A | 0 | 0 | 10 | 10 |
| Johns Creek B | Winnebago | 0 | 0 | 0 | 0 |
| Hinsdale Central | New Brighton | 0 | 0 | 10 | 10 |