Genetically modified mice with high concentrations of the rate-controlling enzyme in this pathway were deemed "supermice" for their increased activity and lifespan by Richard Hanson. CREB and the coactivator PGC-1 work together to induce this process by promoting cooperativity within a class of corticosteroids. The medication metformin works by inhibiting this pathway. (-5[1])PEP carboxykinase is the rate-limiting enzyme in this pathway, in which (10[1])it catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (-5[3])(fah-sfow-uh-naal-pai-ROO-vayt). Three steps in this pathway are deemed (-5[1])"bypass" because they are the reverse of large negative (10[1])free energy steps of glycolysis. In the Cori cycle, this pathway occurs after lactic acid is (-5[1])transported to the liver. For 10 points, name this metabolic pathway that uses smaller organic molecules to synthesize glucose. (10[4]0[2])■END■