An increased bleed risk occurs during cirrhosis due to reduced volumes of a serpin that inactivates this protein. For 10 points each:
[10h] Name this enzyme inhibited by aminocaproic acid. Its zymogen is activated by tPa.
ANSWER: plasmin [accept plasminogen]
[10m] Aminocaproic acid inhibits plasmin by resembling this amino acid, which is recognized by plasmin’s Kringle domains. Histidine, arginine, and this amino acid are basic.
ANSWER: lysine
[10e] Plasmin dissolves fibrin produced during this process mediated by platelets and a namesake enzyme cascade.
ANSWER: clotting [or coagulation]
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