Question

A protein which transfers molecules containing this functional group was targeted by Pfizer’s clinically ineffective inhibitor torcetrapib (“tor-SET-tra-pib”). A subclass of drugs defined by this functional group more often cause an allergic reaction reversed with Intralipid and characterized by tinnitus, a metallic taste, and seizures. Pralidoxime can free up serine-204 of the Ser-His-Glu triad to bind this functional group if it is administered before enzyme “aging” occurs. The hydrolysis of this functional group forms benzoyl·ec·gonine in the metabolism of (*) cocaine. CETP exchanges molecules containing this functional group between HDL (10[1])and LDL. An enzyme that cleaves this functional group is inhibited by organophosphates at the synaptic cleft, preventing it from breaking down acetylcholine. For 10 points, which functional group forms the bonds between the three fatty acid chains and glycerol backbone of triglycerides? ■END■

ANSWER: esters [accept cholesteryl esters or choline esters; accept acetylcholinesterase; prompt on acetylcholine by asking “which functional group is generated by the synthesis of acetylcholine?”; prompt on triglycerides] (The second clue refers to ester local anesthetics, which more commonly cause local anesthetic systemic toxicity (LAST) than amide local anesthetics.)
<Itamar Naveh-Benjamin, Biology>
= Average correct buzz position

Buzzes

PlayerTeamOpponentBuzz PositionValue
Adam FineThe Catastrophic Implosion of Packet SubThe Plague (anime)" was redirected to: "Oran High School Host Club8710

Summary

2023 Chicago Open08/05/2023Y1100%0%0%87.00