Question
This molecule’s initial 37-amino acid form is cleaved and amidated in the brain stem to form its active 30- or 31-amino acid form. For 10 points each:
[10m] Name this incretin that is mimicked by a class of type 2 diabetes drugs that includes semaglutide, which has recently gained popularity as an off-label weight loss drug.
ANSWER: GLP-1 [or glucagon-like peptide 1; accept GLP-1 receptor agonists or glucagon-like peptide-1 receptor agonists or GLP-1-RAs]
[10h] Semaglutide’s substitution of AIB for alanine prevents it from being acted on by an incretin-degrading member of this protease family. Cathepsin C is also a member of this family.
ANSWER: dipeptidyl peptidases [or DPPs; accept either answer followed by an integer between 1 and 8 inclusive]
[10e] Both GLP-1 and semaglutide promote the production of this hormone responsible for lowering blood glucose levels.
ANSWER: insulin
<Adam Fine, Biology>
Summary
| 2023 Chicago Open | 08/05/2023 | Y | 9 | 15.56 | 100% | 44% | 11% |
Data
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| Evans Hall destruction awaiters | In Search of Things Past | 0 | 0 | 10 | 10 |
| The Plague (anime)" was redirected to: "Oran High School Host Club | Quasicrystal Silence | 10 | 0 | 10 | 20 |
| Saint Peter Andre 3000 | Teach Us to Outgrow Our Ladness | 10 | 0 | 10 | 20 |
| The Canadians | Team Name Think Detail | 0 | 0 | 10 | 10 |
| The anti-STOON-dahl cabal (the tall Keyal et al.) | wave2: trimming membership codes 9655377758gp | 10 | 0 | 10 | 20 |
| Curse you, Periplus the Platypus! | [moderator voice] yes that is so tenpointscore! is your team feeling bonuspilled? | 10 | 10 | 10 | 30 |
| Don't be Afraid, the Clown's Afraid Too | Romanos IV Diogenes’ Macaroni Grill | 0 | 0 | 10 | 10 |
| remembrance of lost time | I prefer really not to speak. If I speak I’m in big trouble | 0 | 0 | 10 | 10 |