One cell type described by this term, the chromaffin cells, gives rise to pheo·chromo·cytomas. For 10 points each:
[10m] Name these cells that integrate two major systems. Tumors of these cells, particularly those arising from the GI tract and pancreas, are graded based on the Ki-67 index instead of cellular polymorphisms.
ANSWER: neuroendocrine cells [accept neuroendocrine tumors; prompt on NETs]
[10e] Pheo·chromo·cytomas arise in the chromaffin cells of these glands that produce cortisol. Sympathetic signaling causes these glands to release epinephrine into the blood, integrating the nervous and endocrine systems.
ANSWER: adrenal glands
[10h] Non-pheo·chromo·cytoma neuroendocrine tumors may cause this para·neo·plastic syndrome associated with serotonin overproduction. This condition results in flushing, diarrhea, and more rarely, heart complications.
ANSWER: carcinoid syndrome
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