Synthetic or viral inhibition of caspase-8 prevents extrinsic apoptosis, shifting cells to this second-line death program instead. For 10 points each:
[10h] Name this highly immunogenic form of programmed cell death mediated by RIPK3 (“rip-K-3”) and its substrate, MLKL.
ANSWER: necroptosis (“neh-crop-TOH-sis”) [accept intrinsic necroptosis or extrinsic necroptosis; prompt on regulated necrosis; reject “necrosis” or “apoptosis”]
[10e] While apoptosis shuts down cellular functions like translation that consume this molecule, those processes persist during necroptosis and contribute to the lethal decline in intracellular concentrations of this energy currency.
ANSWER: ATP [or adenosine triphosphate]
[10m] A major drain of ATP during necroptosis is hyperactivation of PARP-1 (“parp one”), an enzyme involved in this process. Other ATP-draining enzymes involved in this process in eukaryotes include MutS and MutL homologues.
ANSWER: DNA repair [accept nucleotide excision repair or NER; accept base excision repair or BER; accept mismatch repair or MMR; accept non-homologous end joining or NHEJ; accept single-stranded break repair or SSB repair; accept double-stranded break repair or DSB repair; prompt on repair; prompt on DNA damage response]
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