Symptoms of this disease can be treated by NMDA receptor antagonists like memantine. Hereditary cases of this disease are often associated with mutations in the genes PSEN-1 and PSEN-2. Patients with Down syndrome are often susceptible to a version of this disease caused by an extra copy of the APP gene. This disease is caused by the cleavage of a protein by beta-secretase and gamma-secretase rather than alpha-secretase. A genetic marker for this disease is the E4 variant of Apolipoprotein E. Treatments for this disease attempt to reduce the number of tau protein“tangles” and (10[1])beta-amyloid plaques. (10[1])For 10 points, name this neurodegenerative (10[1])disease that is (10[1])the most common cause of dementia. ■END■ (10[1])