Every arm of the 200-megadalton molecule PG5 is terminated by one of these functional groups but protected by a Boc (“bock”). For 10 points each:
[10e] Name this functional group that is protected by Boc or Fmoc (“F-mock”) during peptide synthesis, since it is at the N-terminus of every protein.
ANSWER: amine [or amino group; or NH2 group]
[10m] Synthetic chemists prefer Boc to Fmoc because its deprotection has a higher value for this green chemistry metric. It equals the molecular weight of the desired product divided by the total molecular weight of the reactants.
ANSWER: atom economy [or atom efficiency; or atom percentage; prompt on efficiency; prompt on economy or percentage; reject “yield”]
[10h] Boc-protected peptides are cleaved off the surface using an acidic cocktail containing TIPS, which reacts as one of these nucleophiles to suck up reactive trityl (“TRY-till”) cations. In general, these species react stoichiometrically with inhibitors to prevent side reactions.
ANSWER: molecular scavengers
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